Patients with advanced stage disease were treated with 6 cycles of B-GIFOX. Patients with stage IB/IX or II were treated with 4 cycles of B-GIFOX followed by radiotherapy. Patients with histologically confirmed NKTL with stage IB or bulky(X) and stage II-IV disease were included. This was an open-labelled prospective phase II study approved by the institutional review board. Hence we conducted a study to evaluate the clinical efficacy of B-GIFOX in patients with newly diagnosed NKTL. We have also previously published a patient with relapsed NKTL that was successfully treated with GIFOX therapy. Further, drug testing in mouse NKTL xenograft suggest gemcitabine (G), oxaliplatin (ox) and ifosfamide (if) were effective in inducing tumor regression. Bortezomib (B) is a potent and reversible proteasome inhibitor which has shown single agent activity in preclinical models of NKTL in vitro and in vivo.
Gene expression profiling of NKTL revealed overexpression of NF-kB. Natural-killer/T-cell lymphoma (NKTL) is a subtype of non-Hodgkin's lymphoma with poor response to conventional chemotherapy.
Image Diffs help you make sure the correct assets go it into your project. Inline Changes are highlighted to take the guesswork out of your diffs. Gifox 1.4.0 – Record your screen as an animated GIF.This file was last analysed by Free Download Manager Lib 2 days ago. The download is provided as is, with no modifications or changes made on our side.
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